Publications
Preprints & working papers.
Vitacore publishes preprint-first on arXiv, bioRxiv, or medRxiv, followed by peer-reviewed journal submission with open-access preference. The June 2026 sprint comprises three theoretical and perspective papers.
2026 sprint
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Technical Note in preparation Towards a Formal Signal Processing Specification for Photon-Counting CT Radiomics: Addressing the Feature Instability Problem through Signal Chain Characterisation
Photon-counting CT (PCCT) represents the most significant hardware transition in clinical CT in five decades, yet radiomics pipelines built on conventional-CT signal characteristics remain formally unvalidated for PCCT data. This Technical Note applies formal signal-chain analysis to the PCCT radiomics pipeline, deriving theoretical stability conditions for IBSI feature classes under PCCT acquisition parameter variation and validating these conditions against published 2023–2025 phantom-study findings.
- Preprint
- arXiv · eess.SP, cross-listed physics.med-ph
- Journal
- European Radiology Experimental (Springer Nature, open access)
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Opinion in preparation Spatial Transcriptomics Cell Type Deconvolution as a Blind Source Separation Problem: A Formal Signal Processing Framework
Twenty or more spatial-transcriptomics deconvolution algorithms have been published with inconsistent benchmark results. None has been derived from formal signal-separation theory. This Opinion frames deconvolution as a blind source separation problem, derives identifiability conditions, maps existing algorithms to their BSS equivalents, and proposes principled algorithm selection criteria based on formal signal-model assumptions.
- Preprint
- bioRxiv · Bioinformatics
- Journal
- Briefings in Bioinformatics (Oxford University Press)
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Perspective in preparation Information-Theoretic Limits of Circulating Tumour DNA Detection: A Signal Detection Theory Framework for Clinical Threshold Specification
Clinical detection thresholds for ctDNA assays are set empirically without theoretical foundation. This Perspective applies the Neyman-Pearson framework and Shannon information theory to derive the minimum detectable tumour fraction in closed form as a function of sequencing depth and error rate, calculate the channel capacity of ctDNA sequencing assays, and situate current clinical assays relative to theoretical limits.
- Preprint
- medRxiv · Oncology
- Journal
- npj Precision Oncology (Nature Portfolio)
Prior work
Earlier publications by the Founding Research Director, prior to the establishment of Vitacore Research Collaborative.
- 2018 · Walker A. et al. Real-time trauma scoring and survival prediction using wearable physiological sensing. IEEE EMBC 2018.
- 2017 · Walker A. et al. ECG classification with HL7-FHIR interoperability for wearable clinical telemetry. IEEE conference paper.